リアルワールドデータについて

製薬企業におけるRWD系データベースのユースケースとこれからの課題

著者/発表者

但馬匠, 鈴木將之, 小島真一, 鈴木雅, 後藤聖, 後川芳輝

製薬企業でのリアルワールドデータ活用の取り組み

―電子カルテデータを利用した実臨床の把握および治験データ再現の可能性について―

著者/発表者

鈴木 將之, 但馬 匠, 奥村 文和, 水谷 隆二,久保 由貴, 小島 史照, 三由 文彦, 近藤 和興,鈴木 雅

Electronic Health Record Nested Pragmatic Randomized Controlled Trial of a Reminder System for Serum Lithium Level Monitoring in Patients with Mood Disorder: KONOTORI study protocol

著者/発表者

Seki T, Aki M, Kawashima H, Miki T, Tanaka S, Kawakami K, Furukawa TA

Comparative effectiveness of SGLT2 inhibitors vs other classes of glucose-lowering medications on renal outcome in type 2 diabetes.

著者/発表者

Takeuchi M, Ogura M, Minoura T, Inagaki N, Kawakami K

Validity of claims diagnosis codes for cardiovascular diseases in diabetes patients in Japanese administrative database

著者/発表者

Ono Y, Taneda Y, Takeshima T, Iwasaki K, Yasui A

A Real-World Observational Study Evaluating the Probability of Glycemic Control with Basal Insulin or Glucagon-Like Peptide-1 Receptor Agonist in Japanese Patients with Type 2 Diabetes

著者/発表者

Baxter M, Morimoto Y, Tamiwa M, Hattori M, Peng XV, Lubwama R, Maegawa H

Influence of acetaminophen on renal function: a longitudinal descriptive study using a real‑world database

著者/発表者

Ide K, Fujiwara T, Shimada N, Tokumasu H

A Real-World, Observational Study of the Initiation, Use, and Effectiveness of Basal-Bolus or Premixed Insulin in Japanese People With Type 2 Diabetes

著者/発表者

Miyoshi H, Baxter M, Kimura T, Hattori M, Morimoto Y, Marinkovich D, Tamiwa M, Hirose T

Variation of treatment decision-making for laryngeal cancer in Japan a retrospective observational study using a claim- and electronic medical record-based database

著者/発表者

Takashi Fujiwara, Masanobu Mizuta, Eishu Nango, Hisanobu Tamaki

Improvement in the appropriate antimicrobial usage for treating pediatric acute otitis media in Japan:
A descriptive study using nation-wide electronic medical record data

著者/発表者

Kono M, Sugita G, Itahashi K, Sasagawa Y, Iwama Y, Hiraoka S, Otani M, Hotomi M

Identification and Validation of Hemophilia-Related Outcomes on Japanese Electronic Medical Record Database (Hemophilia-REAL V Study)

著者/発表者

Fujiwara T, Miyakoshi C, Kanemitsu T, Okumura Y, Tokumasu H

Factors affecting creatine phosphokinase elevation during daptomycin therapy using combination of machine learning and conventional methods

著者/発表者

Shungo Imai, Hitoshi Kashiwagi, Yuki Sato, Takayuki Miyai, Mitsuru Sugawara, Yoh Takekuma

Association between biopsies for anti-neutrophil cytoplasmic antibody-associated vasculitis and prognosis:
a retrospective cohort study

著者/発表者

Hiroyuki Hashimoto, Masato Takeuchi, Koji Kawakami

Utilization of glucagon-like peptide-1 receptor agonists and changes in clinical characteristics in type 2 diabetes mellitus patients by chronic kidney disease stage in Japan: A descriptive observational study using nationwide electronic medical record databases

著者/発表者

Naoki Hirose, Naoto Tsujimoto, Taeko Katayose, Rina Chin

Using Japanese big data to investigate novel factors and their high-risk combinations that affect vancomycin-induced nephrotoxicity

著者/発表者

Shungo Imai, Shota Kadomura, Takayuki Miyai, Hitoshi Kashiwagi, Yuki Sato, Mitsuru Sugawara, Yoh Takekuma

Initiating SGLT2 inhibitor therapy to improve renal outcomes for diabetic persons eligible for an intensified glucose-lowering regimen: hypothetical intervention using parametric g-formula modeling

著者/発表者

Masato Takeuchi, Masahito Ogura, Nobuya Inagaki, Koji Kawakami

Accuracy of algorithms to identify patients with a diagnosis of major cancers and cancer-related adverse events in an administrative database: a validation study in an acute care hospital in Japan

著者/発表者

Takashi Fujiwara, Takashi Kanemitsu, Kosei Tajima, Akinori Yuri, Masahiro Iwasaku, Yasuyuki Okumura, Hironobu Tokumasu

Association of maternal prepregnancy weight and early childhood weight with obesity in adolescence: A population-based longitudinal cohort study in Japan

著者/発表者

Satomi Yoshida,Takeshi Kimura,Masahiro Noda,Masato Takeuchi,Koji Kawakami

The General Understanding and Perceptions of the Practical Use of School Health Records: A Questionnaire Survey of Parents from Seven Local Municipalities in Japan

著者/発表者

Kazuki Ide, Satomi Yoshida, Takeshi Kimura, Yasuko Oita, Koji Kawakami

Longitudinal study of body mass index and percentage of overweight in Japanese children grouped by maturity

著者/発表者

Reiko Masubuchi, Masahiro Noda, Satomi Yoshida and Koji Kawakami

Burden of congenital hemophilia A requiring treatment in Japan: The HIKOBOSHI study

著者/発表者

Azusa Nagao, Akiko Ioka, Takao Nakamura, Yoichi Murakami, Misako Makishima, Norihiro Okada,Michio Sakai

Seasonal influenza, its complications and related healthcare resource utilization among people 60 years and older: A descriptive retrospective study in Japan

著者/発表者

Yuriko Hagiwara ,Kazumasa Harada ,Joshua Nealon ,Yasuyuki Okumura,Takeshi Kimura,Sandra S. Chaves

Early corticosteroid dose tapering in patients with acute exacerbation of idiopathic pulmonary fibrosis

著者/発表者

Keisuke Anan, Yuki Kataoka, Kazuya Ichikado, Kodai Kawamura, Takeshi Johkoh, Kiminori Fujimoto, Kazunori Tobino, Ryo Tachikawa, Hiroyuki Ito, Takahito Nakamura, Tomoo Kishaba, Minoru Inomata, Tsukasa Kamitani, Hajime Yamazaki, Yusuke Ogawa & Yosuke Yamamoto

Machine Learning Models Predicting Cardiovascular and Renal Outcomes and Mortality in Patients with Hyperkalemia

著者/発表者

Eiichiro Kanda, Suguru Okami, Shun Kohsaka, Masafumi Okada, Xiaojun Ma, Takeshi Kimura, Koichi Shirakawa, Toshitaka Yajima

Persistence and Safety of Golimumab in Elderly Patients with Rheumatoid Arthritis and Renal Dysfunction in a Real-World Setting

著者/発表者

Seiji Yokoyama, Yutaka Ishii, Junya Masuda

Impact of COVID-19 pandemic-associated reduction in respiratory viral infections on childhood asthma onset in Japan

著者/発表者

Naomi Matsumoto, Tomoka Kadowaki, Satoe Takanaga, Masanori Ikeda, Takashi Yorifuji

Relationship between the dose titration and adherence of mirogabalin in patients with peripheral neuropathic pain depending on renal function: a nationwide electronic medical record database

著者/発表者

Karin Kato, Sho Kodama, Kazuhito Shiosakai, Takeshi Kimura

Descriptive epidemiology of COVID-19 in Japan 2020: insights from a multihospital database

著者/発表者

Masato Takeuchi, Shoichiro Inokuchi, Takeshi Kimura, Narumi Eguchi, Koji Kawakami, Tai Takahashi

The effect of preoperative rehabilitation on the prevention of postoperative ileus in colorectal cancer patients

著者/発表者

Kenta Ushida, Yoshinori Yamamoto, Shinsuke Hori, Miho Shimizu, Yuki Kato, Yuji Toiyama, Yoshinaga Okugawa, Akio Shimizu, Ryo Momosaki

Risk of parkinsonism and related movement disorders with gabapentinoids or tramadol: a case-crossover study

著者/発表者

Ri Kairi, Fukasawa Toshiki, Yoshida Satomi, Takeuchi Masato, Kawakami Koji

Use of Japanese big data from electronic medical records to investigate risk factors and identify their high-risk combinations for linezolid-induced thrombocytopenia

著者/発表者

Yuki Inoue, Yoh Takekuma, Takayuki Miyai, Hitoshi Kashiwagi, Yuki Sato, Mitsuru Sugawara & Shungo Imai

Real-World Hepatic Safety of Oral Acetaminophen versus Loxoprofen/Celecoxib: Using a Nationwide Electronic Medical Record Database

著者/発表者

Yasuyuki OKUMURA, Takeshi KIMURA, Shoichiro INOKUCHI, Masahiro OKAMOTO, Toshio TAKANO, Masumi MIYAKE, Yuji KUMAGAI

Electronic Health Record Nested Reminders for Serum Lithium Level Monitoring in Patients with Mood Disorder: Randomized Controlled Trial

著者/発表者

Tomotsugu Seki, Morio Aki, Toshi A Furukawa, Hirotsugu Kawashima, Tomotaka Miki, Yujin Sawaki, Takaaki Ando, Kentaro Katsuragi, Takahiko Kawashima, Senkei Ueno, Takashi Miyagi, Shun'ichi Noma, Shiro Tanaka, Koji Kawakami

Survival outcomes among patients with multiple myeloma in the era of novel agents: exploratory assessment using an electronic medical record database in Japan

著者/発表者

Shuji Uno , Shuichi Midorikawa , Kei Inoue , Daisuke Ichikawa , Tomoki Ito , Junya Kuroda , Kenshi Suzuki

Risk Factor Analysis of Vancomycin-Induced Nephrotoxicity in Paediatric Patients Aged 0–1 Year Using Japanese Medical Database

著者/発表者

Takayuki Miyai, Yoh Takekuma, Hitoshi Kashiwagi, Yuki Sato, Shunsuke Nashimoto, Mitsuru Sugawara, and Shungo Imai

Longitudinal impact of the COVID-19 pandemic on the development of mental disorders in preadolescents and adolescents

著者/発表者

Naomi Matsumoto, Tomoka Kadowaki, Satoe Takanaga, Yoshie Shigeyasu, Ayumi Okada, Takashi Yorifuji

Anemia Treatment, Hemoglobin Variability, and Clinical Events in Non-Dialysis-Dependent Chronic Kidney Disease Patients in Japan

著者/発表者

Takahiro Kuragano, Suguru Okami, Sachiko Tanaka-Mizuno, Hidetoshi Uenaka, Takeshi Kimura, Yosuke Ishida, Kanae Yoshikawa-Ryan, Glen James, Takanori Hayasaki

Validity of Using Japanese Administrative Data to Identify Inpatients
With Acute Pulmonary Embolism: Referencing
the COMMAND VTE Registry

著者/発表者

Aki Kuwauchi, Satomi Yoshida, Chikashi Takeda, Yugo Yamashita, Takeshi Kimura,Masato Takeuchi , and Koji Kawakami

Four-year treatment continuation rates of osteoporosis drugs with different dosing intervals throughout Japan

著者/発表者

Koichi Idei, Kazuteru Ryu, Seiji Miura, Kenichi Hiraga, Yohsuke Hayama, Arata Suzuki, Naoki Okubo, Yuji Arai, Kenji Takahashi

Systemic steroid therapy for pneumonic chronic obstructive pulmonary disease exacerbation: A retrospective cohort study

著者/発表者

Akihiro Shiroshita, Keisuke Anan, Masafumi Takeshita, Yuki Kataoka

Treatment of chronic constipation using elobixibat in a real-world setting: a retrospective cohort study using an electronic medical records database in Japan

著者/発表者

Hisanori Masaki, Koji Shimamoto, Shoichiro Inokuchi, Sonoko Ishizaki

Prediction models for in-hospital deaths of patients with COVID-19 using electronic healthcare data

著者/発表者

Hiraga K, Takeuchi M, Kimura T, Yoshida S, Kawakami K

Predicting mortality in pediatric sepsis: A nationwide data analysis using a pediatric sepsis surveillance method

著者/発表者

Shinya Miura, Nobuaki Michihata

Comparative effectiveness of sodium-glucose co-transporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors on liver function in patients with type 2 diabetes in Japan: A real-world data analysis

著者/発表者

Hirokazu Takahashi, Keiko Asakawa, Yoshinori Kosakai, Takumi Lee, Mitsuhiro Rokuda

Glucocorticoid treatment and clinical outcomes in patients with polymyalgia rheumatica: A cohort study using routinely collected health data

著者/発表者

Yoshiya Tanaka, Shinichi Tanaka, Toshiki Fukasawa, Shoichiro Inokuchi, Hidetoshi Uenaka, Takeshi Kimura, Toshiya Takahashi, Naoto Kato

Persistent Risk of Developing Autoimmune Diseases Associated With COVID-19
An Observational Study Using an Electronic Medical Record Database in Japan

著者/発表者

Shoichiro Inokuchi, Koji Shimamoto

Population characteristics and diagnosis rate of chronic kidney disease by eGFR and proteinuria in Japanese clinical practice: an observational database study

著者/発表者

Tetsuhiro Tanaka, Shoichi Maruyama, Noriharu Chishima, Hiroki Akiyama, Koji Shimamoto, Shoichiro Inokuchi, Keiji Yokota, Asuka Ozaki

Renal outcomes with sodium-glucose cotransporter 2 inhibitors in Japanese people with grade 3 chronic kidney disease and type 2 diabetes: Analysis of medical administrative databases

著者/発表者

Hiroaki Iijima, Maki Gouda, Hideaki Hida, Kazumi Mori-Anai, Akiko Takahashi, Ryoichi Minai, Hideki Ninomiya, Yoshiyuki Saito, Atsushi Miyawaki, Jun Wada

Effect of multidisciplinary care on diabetic kidney disease: a retrospective cohort study

著者/発表者

Hayashi A, Mizuno K, Shinkawa K, Sakoda K, Yoshida S, Takeuchi M, Yanagita M, Kawakami K

リアルワールドデータを用いた，本邦における慢性便秘症に対するマクロゴール＋電解質製剤を中心とした治療状況
―後方視的データベース研究―

著者/発表者

正木 久典, 嶋本 公司, 猪口 翔一朗, 石崎 園子

A new electronic medical record database linked to claims data and discharge abstract data (the RWD database) in Japan: Study design and profile

著者/発表者

Yasuyuki Okumura, Takashi Fujiwara, Hironobu Tokumasu, Takeshi Kimura, Shiro Hinotsu

Initiation and continuation of pharmacological therapies in patients hospitalized for heart failure in Japan

著者/発表者

Suguru Okami, Coralie Lecomte, Hanaya Raad, Mireia Aguila, Zuzana Mohrova, Makiko Takeichi, Takanori Tsuchiya, Christoph Ohlmeier, Thomas Evers, Alexander Michel

Machine learning models for prediction of HF and CKD development in early-stage type 2 diabetes patients

著者/発表者

Eiichiro Kanda, Atsushi Suzuki, Masaki Makino, Hiroo Tsubota, Satomi Kanemata, Koichi Shirakawa, Toshitaka Yajima

Factors affecting the antimicrobial changes during treatment for acute otitis media in Japan: A retrospective cohort study using classification and regression trees (CART) analysis

著者/発表者

Masamitsu Kono, Daichi Murakami, Hideki Sakatani, Katsuya Okuda, Tetsuya Kinoshita, Masayoshi Hijiya, Takuro Iyo, Tatsuya Shiga, Yohei Morita, Koju Itahashi, Yuji Sasagawa, Yasuhiro Iwama, Tomohisa Yamaguchi, Muneki Hotomi

Outcomes of Early Versus Delayed Anemia Treatment in Nondialysis-Dependent CKD

著者/発表者

Kouji Kawai, Manabu Ishii, Yoshimasa Kokado, Takashi Horikawa, Junichi Hoshino

A nation-wide medical record database study: Value of hepatitis B surface antigen loss in chronic hepatitis B patients in Japan

著者/発表者

Kinya Okada, Yoshikazu Nakayama, Jennings Xu, Yang Cheng, Junko Tanaka

Impact of COVID-19 pandemic on physical health amongst children: Difference-in-differences analyses of nationwide school health checkup database

著者/発表者

Yusuke Okubo, Kazue Ishitsuka, Atsushi Goto

Safety risks of interstitial lung disease upon real-world usage of Janus kinase inhibitors and biologics for patients with autoimmune diseases: epidemiological study using nationwide electronic medical record database in Japan

著者/発表者

Mihoko Yabuuchi, Kazuhito Yokoyama